Linkage disequilibrium and haplotype block structure in Portuguese Holstein cattle
نویسندگان
چکیده
منابع مشابه
Linkage disequilibrium decay and haplotype block structure in the pig.
Linkage disequilibrium (LD) may reveal much about domestication and breed history. An investigation was conducted, to analyze the extent of LD, haploblock partitioning, and haplotype diversity within haploblocks across several pig breeds from China and Europe and in European wild boar. In total, 371 single-nucleotide-polymorphisms located in three genomic regions were genotyped. The extent of L...
متن کاملExtent of linkage disequilibrium in Holstein cattle in North America.
The success of fine-scale mapping and genomic selection depends mainly on the strength of linkage disequilibrium (LD) between markers and causal mutations. With Lewontin's measure of LD (known as D'), high levels of LD that extend over several million base pairs have been reported in livestock. However, this measure of LD can be strongly biased upward by small samples and by low allele frequenc...
متن کاملLinkage disequilibrium and haplotype block structure in six commercial pig lines.
Linkage disequilibrium (LD) across the genome is critical information for association studies and genomic selection because it determines the number of SNP that should be used for a successful association analysis and genomic selection. Linkage disequilibrium also influences the accuracy of genomic breeding values. Some studies have demonstrated that SNP in strong LD are organized into discrete...
متن کاملLinkage disequilibrium, haplotype evolution, and the coalescent
Linkage disequilibrium has become an important tool for fine-scale mapping. We argue that in order to understand the pattern of association between alleles at different loci, as well as DNA sequence polymorphism, it is useful first to consider the underlying genealogy of the chromosomes. The stochastic process known as the coalescent provides an extremely convenient way of modeling such genealo...
متن کاملLinkage disequilibrium and persistence of phase in Holstein-Friesian, Jersey and Angus cattle.
When a genetic marker and a quantitative trait locus (QTL) are in linkage disequilibrium (LD) in one population, they may not be in LD in another population or their LD phase may be reversed. The objectives of this study were to compare the extent of LD and the persistence of LD phase across multiple cattle populations. LD measures r and r(2) were calculated for syntenic marker pairs using geno...
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ژورنال
عنوان ژورنال: Czech Journal of Animal Science
سال: 2018
ISSN: 1212-1819,1805-9309
DOI: 10.17221/56/2017-cjas